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Cancer’s Metabolic Pathways; that I have inhibited.

Updated 19/08/19

My Glutamine Pathway Inhibitors

Goserlin: Zolodex implant each month from oncologist inhibits IGF-1

Berberine: 500mg, 2 x daily, total daily= 1000mg

Loratadine: 10mg daily

Hydroxy Chloroquine: taking approx. 1 week of every 6

Dipyridamole: 200mg slow release Persantin 3 x daily (7am, 2pm, 9pm) daily total = 600mg

EGCG in Green Tea: 2-3 cups each day decaf and 1 x 725mg decaf capsule at dinner.

Curcumin phytosome with meriva: 500mg x 2, 3 x daily = 1500mg with meals

Ursolic Acid in Tulsi Tea with meal to wash down curcumin capsules.

Japanese Knotweed aka Hu Zang root powder from which Resveratrol comes Total taken with evening meal, 1 tsp stirred into in the tulsi tea.


My Glucose Pathway Inhibitors

Quercetin: 600mg 3 x daily total = 1800mg

Curcumin Phytosome with Meriva: as mentioned previously.

Liposomal Vit C: currently enjoying 5g (about 30ml) x 2-3 x daily and I have 4 drops of Zinc chelate I water as a chaser.

Melatonin: currently taking 180mg at 7pm ( 3 x 60mg pure melatonin capsules from online supplier Perfect Vitamin- I worked my way up gradually using products on herb)

Low GI Diet: More plant foods, light on carbs and very light on meat.
Enjoy most days: olive oil, olives, mushrooms, walnuts, chia seeds, broccoli, green apples, lemon juice, raw cacao, organic carrots, macadamia nuts, turmeric, ginger, cauliflower, sweet potato, pumpkin, pumpkin seeds, berries, quinoa, mackerel, trout, good eggs, no dairy other than a sprinkle of good quality parmesan cheese. If we have a chicken dinner, I eat only half little wing where I once ate a whole wing and a leg. We eat fish in small portions these days instead of red meat.

Berberine
: 500mg, as mentioned previously.

Keto-7 DHEA: safe alternative for estrogen driven cancers. Not taking just now, but have the Life Extension brand bought from private eBay USA seller as it’s not available here in Australia to take if when I do want it.

Japanese Knotweed aka Hu Zang root powder again a warning goes with this supplement and I’m currently having a total of 1 teaspoon mixed into my Tulsi tea at dinner as mentioned previously.

Liposomal Vitamin C: currently I am having 5mg (25-30ml Lip C) 2- 3 times each day away from other sups. before lunch, late afternoon and before bed.


My Fatty Acid Pathway Inhibitors

Berberine: as mentioned previously.

Garcinia Cambogia 500mg once daily for Hydroxycitrate Acid which I have with R-Alpha Lipoic Acid 100mg https://sci-hub.tw/10.1038/s41598-019-39109-1

Aspirin 100mg each day , and I will take up to 3 x 300mg daily for a few days.

Nicotinamide (flush free niacin) 500mg x 3 times daily.

Citrus Bergamot: 500mg x 3 times daily with meals.

Dipyridamole: as mentioned previously.

Tocotrienols: Delta fraction 250mg once daily at breakfast ( 2 x 125mg caps)

Red Yeast Rice: 600mg 1x daily

Oils: Avoiding rancid oils adding extra good olive oil, + omega 3, 6 and 7

Abnormal Cell Signalling regulators that I currently take:

for Sonic Hedgehog signalling I take

Berberine:as mentioned previously. My 1000mg daily total covers 5 metabolic pathways and this cell signalling for me and I have a milk thistle tablet each day to help my liver cope with this much Berberine and I give the berberine a rest from time to time..say, a month off after 6-8wks of daily use.

Mebendazole: 200mg x 3 consecutive days each week (4 days off each week) chewed well and swallowed with a dessert spoon of olive oil. Or I have taken for 4-6 weeks daily, then had a break for 4-6weeks. Recently I took for one week alongside Mebendazole 200mg and everything else here. I can purchase from my local chemist.

Sonic Hedgehog signalling is abnormal in many cancers including breast cancer:

The role of the Hedgehog signaling pathway in cancer: A comprehensive review. – PubMed – NCBI

Mebendazole as a Hedgehog Inhibitor.
https://www.ncbi.nlm.nih.gov/pubmed/29274272

Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546096/

Metformin also exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer and I am not currently taking Metformin
https://www.ncbi.nlm.nih.gov/pubmed/25999130

for regulation of WNT signalling, which induces bone metastases in breast cancer, I take

Aspirin: as mentioned previously.
Dipyridamole: as mentioned previously.
Vitamin D3: 5000IU at breakfast taken with 90mcg Vit-K2
Tocotrienols: Delta fraction 250mg with breakfast as previously mentioned

WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth
https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr2317

A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963808/

for regulating Notch signalling I take

Sulforaphane: 250mg 2 x daily with meal and most of these 2 meals contain lightly cooked broccoli and cauliflower cooked

Quercetin: as mentioned previously.

The Notch Pathway in Breast Cancer Progression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077551/

Sulforaphane: Notch Activation Is Dispensable for D, L-Sulforaphane-Mediated Inhibition of Human Prostate Cancer Cell Migration
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044957

Quercetin: Notch Inhibitors for Cancer Treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732476/

I could add Luteolin
Mechanism of metastasis suppression by luteolin in breast cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003288/


for Toll Like Receptors (TLR’s) I take

TLR’s-3, 4 & 9

Berberine: as mentioned previously.

Hydroxy Chloroquine: 200mg daily for 1 week every 4-6 weeks. 
I timed this so that I took the Mebendazole at the same time, last time.

Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis | BMC Cancer | Full Text
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-10-665

TLR4 Promotes Breast Cancer Metastasis via Akt/GSK3β/β-Catenin Pathway upon LPS Stimulation. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/28296189

Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/29365334

Hydroxychloroquine efficiently suppresses inflammatory responses of human class-switched memory B cells via Toll-like receptor 9 inhibition. – PubMed – NCBI https://www.ncbi.nlm.nih.gov/pubmed/29981383

Indentification of breast cancer subtypes sensitive to HCQ-induced autophagy inhibition. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/31488317

Recent progress in the development of Toll-like receptor (TLR) antagonists: Expert Opinion on Therapeutic Patents: Vol 26, No 6
https://www.tandfonline.com/doi/abs/10.1080/13543776.2016.1185415


for Integrins which contribute to the progression of breast cancer I take

Dipyridamole: as mentioned previously

Increased β1 Integrin Is Associated with Decreased Survival in Invasive Breast Cancer | Cancer Research
http://cancerres.aacrjournals.org/content/67/2/659.short

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies | JCB
http://jcb.rupress.org/content/137/1/231.abstract

Dipyridamole enhances an anti‐proliferative effect of interferon in various types of human tumor cells – Suzuki – 1992 – International Journal of Cancer – Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.2910510420

Inhibition of Metastases by Anticoagulants | JNCI: Journal of the National Cancer Institute | Oxford Academic
https://academic.oup.com/jnci/article/91/1/22/2549


for inhibiting Estrogen I take

Hormone therapies incl. Goserlin which is my monthly Zolodex implant from my oncologist.

Aspirin: as mentioned previously.

Melatonin: as mentioned previously.

Tocopherols: 400IU at lunch each day.


Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms – Amin – 2019 – Journal of Cellular Biochemistry – Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28832

Frontiers | Co-administering Melatonin with an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-positive Breast Cancer | Oncology
https://www.frontiersin.org/articles/10.3389/fonc.2019.00525/abstract

Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-γ
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753525/

Postmenopausal women who regularly use aspirin and other analgesics (known as painkillers) have lower estrogen levels, which could contribute to a decreased risk of breast or ovarian cancer.https://www.sciencedaily.com/releases/2010/03/100323133043.htm



for Epidermal Growth Factor (EGF) I am already taking the following

Milk Thistle: as mentioned previously.
Berberine: as mentioned previously
EGCG
: green tea as mentioned previously
Curcumin: as mentioned previously

Milk Thistle: Silibinin Suppresses EGFR Ligand-induced CD44 Expression through Inhibition of EGFR Activity in Breast Cancer Cells
http://ar.iiarjournals.org/content/31/11/3767.shor

for Interleukins which are linked to progression in breast cancer I am already taking

Aspirin: as mentioned previously


for PPAR I am taking

which doesn’t contribute to early stages of Breast Cancer but does contribute to fatty acid oxidation used by cancer in later stages to spread to other organs.

Citrus Bergamot: as mentioned previously

Red Yeast Rice: as mentioned above

Berberine:
as mentioned previously

Omega-3:
In daily diet of chia seeds, walnuts, mackerel, and the cod liver oil mentioned below.

Vit -A:
600mg quality refridgerated Cod Liver oil with lunch.

Vit-D3:
as mentioned previously.

Omega -7
: 450mg Sea Buckthorn Oil with lunch daily.

Ginger Powder: 1 teaspoon in tea with each meal
https://www.ncbi.nlm.nih.gov/pubmed/18813412

And there’s more:

My Healthy Gut and Happy Liver

Micro-biome

Pro-biotic: weekly
Sauerkraut: tablespoon each day with meal
Raw cacao powder: tablespoon in my breakfast each day.

Liver

Milk Thistle: as mentioned previously.
Sunflower Lecithin Liposomal Vitamin C each day as mentioned previously.
Food: Fresh Lemon Juice, Green Apple and Spirulina with Chia with Ginger Powder for my first breakfast.

Ant-viral medication

Valaciclovir or Valtrex: 500mg x 1 with lunch

A herpes anti-viral drug prescribed by GP.
Study shows specific type of herpes could cause breast cancer

https://www.healthimaging.com/topics/breast-imaging/study-shows-specific-type-herpes-could-cause-breast-cancer

Matrix Metallo-Proteinase Inhibitors I take

Dipyridamole: as mentioned previously.

Mebendazole: 200mg each day first week of each month

Glucosamine Sulphate: 750mg each x 2 with lunch daily

Dipyridamole decreases inflammatory metalloproteinase-9 expression and release by human monocytes. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/23238437

Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/31480477


Glucosamine sulfate suppresses the expression of matrix metalloproteinase-3 in osteosarcoma cells in vitro
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000453/

Tocotrienols

Delta-Fraction Tocotrienals: 125mg x 2 with breakfast, total 500mg daily

DeltaGOLDtm being 90% delta-trocotrienals and 10% gamma tocotrienals from Vitamin E. Brand: Life Extension
Yes another good supplement for the Mevolonate Pathway and the tocotrienols many other anticancer actions.
The Mevolonate pathway is important to me given my breast cancer metastases to my bones and currently take the Citrus Bergamot 3 x daily for the Mevolonate path too.
https://www.clinicaleducation.org/resources/reviews/gods-nuclear-weapons-and-potent-pathways-how-gamma-tocotrienol-works-molecular-magic-the-mevalonate-pathway/
https://academic.oup.com/carcin/article/33/2/233/2463536

Vitamin B Complex

1 x Vitamin B Complete Sustained Release: 1 tablet with breakfast
Contains: B1 100mg,B2 80mg, B2 100mg, B5 120mg,B6 75mg,Folic Acid 400mcg, B12 100mcg, Choline bitartrate 50mg, Inositol 50mg, Biotin 50mcg, Ascorbic Acid 200mg

To learn more about the private online healing cancer study support group that I created to help me understand all of this very sensible non-sense please visit: www.myhealingcommunity.com


To book an hour long support call with me visit:
https://app.acuityscheduling.com