Featured

Cancer’s Metabolic Pathways; that I have inhibited.

Updated 19/08/19

My Glutamine Pathway Inhibitors

Goserlin: Zolodex implant each month from oncologist inhibits IGF-1

Berberine: 500mg, 2 x daily, total daily= 1000mg

Loratadine: 10mg daily

Hydroxy Chloroquine: taking approx. 1 week of every 6

Dipyridamole: 200mg slow release Persantin 3 x daily (7am, 2pm, 9pm) daily total = 600mg

EGCG in Green Tea: 2-3 cups each day decaf and 1 x 725mg decaf capsule at dinner.

Curcumin phytosome with meriva: 500mg x 2, 3 x daily = 1500mg with meals

Ursolic Acid in Tulsi Tea with meal to wash down curcumin capsules.

Japanese Knotweed aka Hu Zang root powder from which Resveratrol comes Total taken with evening meal, 1 tsp stirred into in the tulsi tea.


My Glucose Pathway Inhibitors

Quercetin: 600mg 3 x daily total = 1800mg

Curcumin Phytosome with Meriva: as mentioned previously.

Liposomal Vit C: currently enjoying 5g (about 30ml) x 2-3 x daily and I have 4 drops of Zinc chelate I water as a chaser.

Melatonin: currently taking 180mg at 7pm ( 3 x 60mg pure melatonin capsules from online supplier Perfect Vitamin- I worked my way up gradually using products on herb)

Low GI Diet: More plant foods, light on carbs and very light on meat.
Enjoy most days: olive oil, olives, mushrooms, walnuts, chia seeds, broccoli, green apples, lemon juice, raw cacao, organic carrots, macadamia nuts, turmeric, ginger, cauliflower, sweet potato, pumpkin, pumpkin seeds, berries, quinoa, mackerel, trout, good eggs, no dairy other than a sprinkle of good quality parmesan cheese. If we have a chicken dinner, I eat only half little wing where I once ate a whole wing and a leg. We eat fish in small portions these days instead of red meat.

Berberine
: 500mg, as mentioned previously.

Keto-7 DHEA: safe alternative for estrogen driven cancers. Not taking just now, but have the Life Extension brand bought from private eBay USA seller as it’s not available here in Australia to take if when I do want it.

Japanese Knotweed aka Hu Zang root powder again a warning goes with this supplement and I’m currently having a total of 1 teaspoon mixed into my Tulsi tea at dinner as mentioned previously.

Liposomal Vitamin C: currently I am having 5mg (25-30ml Lip C) 2- 3 times each day away from other sups. before lunch, late afternoon and before bed.


My Fatty Acid Pathway Inhibitors

Berberine: as mentioned previously.

Garcinia Cambogia 500mg once daily for Hydroxycitrate Acid which I have with R-Alpha Lipoic Acid 100mg https://sci-hub.tw/10.1038/s41598-019-39109-1

Aspirin 100mg each day , and I will take up to 3 x 300mg daily for a few days.

Nicotinamide (flush free niacin) 500mg x 3 times daily.

Citrus Bergamot: 500mg x 3 times daily with meals.

Dipyridamole: as mentioned previously.

Tocotrienols: Delta fraction 250mg once daily at breakfast ( 2 x 125mg caps)

Red Yeast Rice: 600mg 1x daily

Oils: Avoiding rancid oils adding extra good olive oil, + omega 3, 6 and 7

Abnormal Cell Signalling regulators that I currently take:

for Sonic Hedgehog signalling I take

Berberine:as mentioned previously. My 1000mg daily total covers 5 metabolic pathways and this cell signalling for me and I have a milk thistle tablet each day to help my liver cope with this much Berberine and I give the berberine a rest from time to time..say, a month off after 6-8wks of daily use.

Mebendazole: 200mg x 3 consecutive days each week (4 days off each week) chewed well and swallowed with a dessert spoon of olive oil. Or I have taken for 4-6 weeks daily, then had a break for 4-6weeks. Recently I took for one week alongside Mebendazole 200mg and everything else here. I can purchase from my local chemist.

Sonic Hedgehog signalling is abnormal in many cancers including breast cancer:

The role of the Hedgehog signaling pathway in cancer: A comprehensive review. – PubMed – NCBI

Mebendazole as a Hedgehog Inhibitor.
https://www.ncbi.nlm.nih.gov/pubmed/29274272

Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546096/

Metformin also exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer and I am not currently taking Metformin
https://www.ncbi.nlm.nih.gov/pubmed/25999130

for regulation of WNT signalling, which induces bone metastases in breast cancer, I take

Aspirin: as mentioned previously.
Dipyridamole: as mentioned previously.
Vitamin D3: 5000IU at breakfast taken with 90mcg Vit-K2
Tocotrienols: Delta fraction 250mg with breakfast as previously mentioned

WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth
https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr2317

A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963808/

for regulating Notch signalling I take

Sulforaphane: 250mg 2 x daily with meal and most of these 2 meals contain lightly cooked broccoli and cauliflower cooked

Quercetin: as mentioned previously.

The Notch Pathway in Breast Cancer Progression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077551/

Sulforaphane: Notch Activation Is Dispensable for D, L-Sulforaphane-Mediated Inhibition of Human Prostate Cancer Cell Migration
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044957

Quercetin: Notch Inhibitors for Cancer Treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732476/

I could add Luteolin
Mechanism of metastasis suppression by luteolin in breast cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003288/


for Toll Like Receptors (TLR’s) I take

TLR’s-3, 4 & 9

Berberine: as mentioned previously.

Hydroxy Chloroquine: 200mg daily for 1 week every 4-6 weeks. 
I timed this so that I took the Mebendazole at the same time, last time.

Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis | BMC Cancer | Full Text
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-10-665

TLR4 Promotes Breast Cancer Metastasis via Akt/GSK3β/β-Catenin Pathway upon LPS Stimulation. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/28296189

Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/29365334

Hydroxychloroquine efficiently suppresses inflammatory responses of human class-switched memory B cells via Toll-like receptor 9 inhibition. – PubMed – NCBI https://www.ncbi.nlm.nih.gov/pubmed/29981383

Indentification of breast cancer subtypes sensitive to HCQ-induced autophagy inhibition. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/31488317

Recent progress in the development of Toll-like receptor (TLR) antagonists: Expert Opinion on Therapeutic Patents: Vol 26, No 6
https://www.tandfonline.com/doi/abs/10.1080/13543776.2016.1185415


for Integrins which contribute to the progression of breast cancer I take

Dipyridamole: as mentioned previously

Increased β1 Integrin Is Associated with Decreased Survival in Invasive Breast Cancer | Cancer Research
http://cancerres.aacrjournals.org/content/67/2/659.short

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies | JCB
http://jcb.rupress.org/content/137/1/231.abstract

Dipyridamole enhances an anti‐proliferative effect of interferon in various types of human tumor cells – Suzuki – 1992 – International Journal of Cancer – Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.2910510420

Inhibition of Metastases by Anticoagulants | JNCI: Journal of the National Cancer Institute | Oxford Academic
https://academic.oup.com/jnci/article/91/1/22/2549


for inhibiting Estrogen I take

Hormone therapies incl. Goserlin which is my monthly Zolodex implant from my oncologist.

Aspirin: as mentioned previously.

Melatonin: as mentioned previously.

Tocopherols: 400IU at lunch each day.


Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms – Amin – 2019 – Journal of Cellular Biochemistry – Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28832

Frontiers | Co-administering Melatonin with an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-positive Breast Cancer | Oncology
https://www.frontiersin.org/articles/10.3389/fonc.2019.00525/abstract

Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-γ
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753525/

Postmenopausal women who regularly use aspirin and other analgesics (known as painkillers) have lower estrogen levels, which could contribute to a decreased risk of breast or ovarian cancer.https://www.sciencedaily.com/releases/2010/03/100323133043.htm



for Epidermal Growth Factor (EGF) I am already taking the following

Milk Thistle: as mentioned previously.
Berberine: as mentioned previously
EGCG
: green tea as mentioned previously
Curcumin: as mentioned previously

Milk Thistle: Silibinin Suppresses EGFR Ligand-induced CD44 Expression through Inhibition of EGFR Activity in Breast Cancer Cells
http://ar.iiarjournals.org/content/31/11/3767.shor

for Interleukins which are linked to progression in breast cancer I am already taking

Aspirin: as mentioned previously


for PPAR I am taking

which doesn’t contribute to early stages of Breast Cancer but does contribute to fatty acid oxidation used by cancer in later stages to spread to other organs.

Citrus Bergamot: as mentioned previously

Red Yeast Rice: as mentioned above

Berberine:
as mentioned previously

Omega-3:
In daily diet of chia seeds, walnuts, mackerel, and the cod liver oil mentioned below.

Vit -A:
600mg quality refridgerated Cod Liver oil with lunch.

Vit-D3:
as mentioned previously.

Omega -7
: 450mg Sea Buckthorn Oil with lunch daily.

Ginger Powder: 1 teaspoon in tea with each meal
https://www.ncbi.nlm.nih.gov/pubmed/18813412

And there’s more:

My Healthy Gut and Happy Liver

Micro-biome

Pro-biotic: weekly
Sauerkraut: tablespoon each day with meal
Raw cacao powder: tablespoon in my breakfast each day.

Liver

Milk Thistle: as mentioned previously.
Sunflower Lecithin Liposomal Vitamin C each day as mentioned previously.
Food: Fresh Lemon Juice, Green Apple and Spirulina with Chia with Ginger Powder for my first breakfast.

Ant-viral medication

Valaciclovir or Valtrex: 500mg x 1 with lunch

A herpes anti-viral drug prescribed by GP.
Study shows specific type of herpes could cause breast cancer

https://www.healthimaging.com/topics/breast-imaging/study-shows-specific-type-herpes-could-cause-breast-cancer

Matrix Metallo-Proteinase Inhibitors I take

Dipyridamole: as mentioned previously.

Mebendazole: 200mg each day first week of each month

Glucosamine Sulphate: 750mg each x 2 with lunch daily

Dipyridamole decreases inflammatory metalloproteinase-9 expression and release by human monocytes. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/23238437

Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/31480477


Glucosamine sulfate suppresses the expression of matrix metalloproteinase-3 in osteosarcoma cells in vitro
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000453/

Tocotrienols

Delta-Fraction Tocotrienals: 125mg x 2 with breakfast, total 500mg daily

DeltaGOLDtm being 90% delta-trocotrienals and 10% gamma tocotrienals from Vitamin E. Brand: Life Extension
Yes another good supplement for the Mevolonate Pathway and the tocotrienols many other anticancer actions.
The Mevolonate pathway is important to me given my breast cancer metastases to my bones and currently take the Citrus Bergamot 3 x daily for the Mevolonate path too.
https://www.clinicaleducation.org/resources/reviews/gods-nuclear-weapons-and-potent-pathways-how-gamma-tocotrienol-works-molecular-magic-the-mevalonate-pathway/
https://academic.oup.com/carcin/article/33/2/233/2463536

Vitamin B Complex

1 x Vitamin B Complete Sustained Release: 1 tablet with breakfast
Contains: B1 100mg,B2 80mg, B2 100mg, B5 120mg,B6 75mg,Folic Acid 400mcg, B12 100mcg, Choline bitartrate 50mg, Inositol 50mg, Biotin 50mcg, Ascorbic Acid 200mg

To learn more about the private online healing cancer study support group that I created to help me understand all of this very sensible non-sense please visit: www.myhealingcommunity.com


To book an hour long support call with me visit:
https://app.acuityscheduling.com

Featured

What I am taking and why.

A whole day’s meds and supps: Current as of June 23rd  2019

1 x capsule Milk Thistle
available online at  i-herb.com

There appears to be many studies on Pubmed suggesting that silymarin from Milk Thistle may exert a strong anticarcinogenic effect against many types of cancer, including breast cancer. It also and anti-oxidant and protects the liver and kidneys.
Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cycli… | Clinical Cancer Research

http://clincancerres.aacrjournals.org/content/4/4/1055.short

Silibinin Suppresses EGFR Ligand-induced CD44 Expression through Inhibition of EGFR Activity in Breast Cancer Cells
http://ar.iiarjournals.org/content/31/11/3767.shor


1 x Vitamin E (as d-alpha tocopherol) 400IU (before dinner )

available online at  i-herb.com

I weigh 54kg so from what I can understand that means 1 a day is plenty to do the job. Someone heavier might take more each day.
Brand: A. C Grace Company ‘Unique E’ online from iherb.com

This page  summarises the findings on tocopherols being a potent aromatase inhibitor.
https://raypeatforum.com/community/threads/vitamin-e-tocopherol-is-a-potent-aromatase-inhibitor.

The mechanisms of anti-cancer activity of tocopherols 1) inhibition of ER (2) increasing peroxisome proliferator activated receptor γ (PPARγ) expression and activity, (3) induction of Nrf2, (4) antioxidative and anti-inflammatory activities, and (5) induction of apoptosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257724/

Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-γ
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753525/


3 x Quercetin 600mg (1 with eah meal )

available online at  i-herb.com
Metabolic Pathway inhibitor: Glucose/Glut 1 and Fatty Acid (FAS)

Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis

https://www.nature.com/articles/srep24049

Quercetin induces apoptosis in triple-negative breast cancer cells via inhibiting fatty acid synthase and β-catenin
http://www.ijcep.com/files/ijcep0036612.pdf


2 x Berberine 500mg (with breakfast & w lunch)

available online at  i-herb.com

Multi Metabolic Pathway inhibitor:
SREBP-1 Acetate
SREBP-1
Insulin
OXPHOS
mTOR
Gln OXPHOS
and supresses hedgehog signalling

Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546096/

Berberine induces apoptosis in breast cancer cells through mitochondrial-dependent pathway
https://doi.org/10.1016/j.ejphar.2010.07.037

A growing body of reports supports the evidence that berberine has anticancer effects, being able to block the proliferation of and to kill cancer cells
https://www.sciencedirect.com/science/article/abs/pii/S000629521200500X

A neo-adjuvant endocrine trial showed a significant association between the increase of SREBP1 expression and lack of clinical response, providing further support for a role of SREBP1 in the acquisition of endocrine resistance in breast cancer.
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-018-1041-8

 

 2 x Citrus Bergamot 500mg (1 x lunch 1 x dinner)

being Citrus Bergamia extract 500mg.  

Brand: Jarrow Formulas available online at  i-herb.com

Metabolic Pathway inhibitor: Fatty Acid/Mevolonate

Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism

https://www.sciencedirect.com/science/article/pii/S0005272818300616?via%3Di&fbclid=IwAR31J5Nb1c-FMAWiEF6xHNfDOvk-LoMW53B95BBnEqtMAwsZ7vNSgW2__GI

Molecular mechanisms of lipid- and glucose-lowering activities of bergamot flavonoids
https://www.sciencedirect.com/science/article/pii/S2213434415300220
 

2 x Garcinia Cambogia (for Hydroxycitrate) 500mg ( 1 x bfast 1 x lunch)

being a cut- in-half tablet of Garcinia Cambogia extract 1000mg. So I’m getting  250mg Hydroxycitric Acid (HYDROXY on the McLelland map) ad the rest is fruit of Garcinia Cambogia.

Brand: Jarrow Formulas available online at  i-herb.com

Metabolic Pathway inhibitor: Fatty Acid/ACLY
ACLY is a cross-link between glucose metabolism and fatty acid synthesis/mevalonate pathways controlled by SREBP-1. Potently inhibited by hydroxycitrate.
ATP Citrate Lyase Inhibitors as Novel Cancer Therapeutic Agents Recent Patents on Anti-Cancer Drug Discovery, 2012, 7, 154-167


6 x Curcumin 500mg
(2 at beginning of each main meal)

being Curcumin Phytosome with Meriva 500mg
I swallow with Tulsi tea for Ursolic Acid
Brand: Jarrow Formulas
available online at  i-herb.com
I swallow my curcumin capsules with Tulsi tea in which I’ve dissolved my Hu Zang for the ursolic acid / resv / curc combo effect.
Metabolic Pathway inhibitor: Glutamine/Glutaminolysis

A combination of ursolic acid and resveratrol or ursolic acid and curcumin prevents glutamine uptake by the cancer cell.

Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
https://www.nature.com/articles/s41698-017-0024-z

Unraveling the Anticancer Effect of Curcumin and Resveratrol
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133053/



Ursolic Acid (1- 2 cups  at beginning & end of lunc and dinner)

being in Tulsi Tea (aka Holy Basil Tea) available online at  i-herb.com
I swallow my Curcumin capsules (see above) with 150ml of the strong Tulsi tea
Brand: I buy organic loose tea leaves in bulk online and drink with each meal. I will mix my other herbs and ginger in it too.

Metabolic Pathway inhibitor: Glutamine/Glutaminolysis 

see above study for Curcumin combo

Ursolic acid, a potential anticancer compound for breast cancer therapy. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/27469428

ECOTEAS Organic Tulsi | Tulsi Benefits
https://yerbamate.com/pages/tulsi-benefits



EGCG
Green Tea 150ml x 3 cups throughout the day.

Brand: I buy organic green tea teabags online at  i-herb.com
Jane’s book says:
“EGCG  reduces angiogenesis and inhibitors of glutamate dehydrogenase (GHD), a precursor of glutamine (an amino acid), the other key nutrient cancer uses with glucose to fuel its growth. (
so…it’s in my map under Glutamine/Glutaminolysis)”
Mclelland, Jane. How to Starve Cancer …without starving yourself: The Discovery of a Metabolic Cocktail That Could Transform the Lives of Millions . Conscious Dreams Publishing. Kindle Edition.
More on this..
https://www.nature.com/articles/18793

And 10 health benefits of green tea supported by studies:
https://www.healthline.com/nutrition/top-10-evidence-based-health-benefits-of-green-tea#section10

1 x EGCG  capsule 98% Polyphenols (1 with dinner)

With dinner : De-caf Mega Green tea Extract 45% EGCG

Brand: Life Extension available online at  i-herb.com
Metabolic Pathway inhibitor: Glutamine/Glutaminolysis



3 x Nicotinamide / Vitamin B3 500mg
(1 with eaach meal)
being Nicotinamide 500mg (niacin flush-free)

available online at  i-herb.com

Metabolic Pathway inhibitor: Helps with all pathways in a complex manner

Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer
https://www.nature.com/articles/s41598-017-03322-7

Nicotinamide also protects the stomach mucus from damage caused by non-steroid anti-inflammatory drugs ( NSAIDs)

And more I’ve read on Nicotinamide / Vitamin B3

http://www.alternative-cancer-care.com/niacin-vitamin-b3-and-cancer.html?fbclid=IwAR31DQy6lWaIz3J4Or9r1Y_YIeP1mpf842KkStGTgJM-TBPXpLVN7i-8noQ



Valaciclovir 500mg x 1 with lunch

A herpes anti-viral drug prescribed by GP after I realized ( reading the book) that the cancer and virus could be closely linked.

Study shows specific type of herpes could cause breast cancer

https://www.healthimaging.com/topics/breast-imaging/study-shows-specific-type-herpes-could-cause-breast-cancer



3 x Dipyridamole 200mg  (7am, 2pm 9pm)
 

being 200mg (sustained release) 

Brand: Persantin available by prescription- and I was able to obtain due to it’s proven anti-viral action and my bloods showing herpes virus.
https://aac.asm.org/content/45/12/3657

Metabolic Pathway inhibitors: Glutamine/Nucleoside Salvage and the Fatty Acid/ SREBP-2

Dipyridamole is an old anti-platelet medication ( stops  blood cells sticking together and so stops them clustering and hiding cancer cells).

Dipyridamole starves cancer of the nucleotides and other proteins and enhances the effects of my anti-viral medication.

Selective potentiation of lometrexol growth inhibition by dipyridamole through cell-specific inhibition of hypoxanthine salvage
https://www.nature.com/articles/bjc1997552

Dipyridamole decreases platelet-derived growth factor levels in human serum.
https://www.ncbi.nlm.nih.gov/pubmed/3579723 


2 x Glucosamine Sulphate 750mg each (with lunch)
 
A matrix metallo-proteinase inhibitor available online at  i-herb.com.

Glucosamine sulfate suppresses the expression of matrix metalloproteinase-3 in osteosarcoma cells in vitro
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000453/


5g x Polygonum Cuspidatum Powder Extract in tulsi tea with dinner.

being whole of Japanese Knotweed AKA Chinese herb Hu Zang powder 500mg dissolved in water and drunk. Metabolic Pathway inhibitors: Pentose Phosphate (P P Pathway) and likely more too. *Warning: not a safe supplement for “everyone” with breast cancer.. until you read this and your doctor agrees that it is not going to cause you harm in regards to estrogen do NOT take it:

Walking a Tightrope: A Perspective of Resveratrol Effects on Brea…: Ingenta Connect

https://www.ingentaconnect.com/content/ben/cpps/2018/00000019/00000003/art00008

A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo | Cell Death & Disease

https://www.nature.com/articles/s41419-018-0635-5?fbclid=IwAR1TwR87xCmFCTrp
JXVF_MLCI8WwJ3ldqOuX244XeZuHmpGORmLNm8Ea934

Polydatin, Natural Precursor of Resveratrol, Promotes Osteogenic Differentiation of Mesenchymal Stem Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036093/



1 x mini Aspirin 100mg  ( just before bed)

being one tablet in water.
Metabolic Pathway inhibitors: Fatty Acids/ FAS

“Aspirin and dipyridamole, both antiplatelet drugs, synergistically serve to break down the platelet clumps and expose the abnormal macrophages to the rest of the immune system”

“The ‘acetyl’ part of aspirin (acetyl salicylic acid) binds to the amino acid serine”

Mclelland, Jane. How to Starve Cancer …without starving yourself: The Discovery of a Metabolic Cocktail That Could Transform the Lives of Millions . Conscious Dreams Publishing. Kindle Edition.

Mechanism of the irreversible inhibition of human cyclooxygenase-1 by aspirin as predicted by QM/MM calculations.

https://www.ncbi.nlm.nih.gov/pubmed/23384979

Ray Peat, PhD on Aspirin – Functional Performance Systems (FPS)
https://www.functionalps.com/blog/2012/04/22/ray-peat-phd-on-aspirin/

https://cowseatgrass.org/2016/05/26/beware-when-rousing-the-bear-with-aspirin/?fbclid=IwAR103haIKFypLLQnzEgm0tjItVqWIOsiituVUNWOamiKG2x4G096v2mhD1U

I found this really interesting read in reference to reversing cancer with the help of high dose Aspirin.
http://www.fuckportioncontrol.com/blog/2016/12/21/cancer?rq=cancer&fbclid=IwAR17oqXoVReMDfy3gCzrazSQFjRiAGlxntSTh0TDO26jlRQaugDE66onqjM

Google: Nicotinamide (Vit  B3) protects the stomach mucus from damage caused by Aspirin


1 x Omega-7  450mg  (w lunch)

being Sea Buckthorn Oil available online at  i-herb.com.
while I’m taking focusing on lowering cholesterol levels this is good oil.
https://www.sciencedirect.com/science/article/pii/S1756464611000028


Lots of Extra Virgin Olive Oil in breaky bowl & splashed on every meal

Modulation of inflammation and immunity by dietary conjugated linoleic acid



1 x Vitamin D3 5000iu with K2
(with b’fast)

being Colecalciferol and available online at  i-herb.com.

A phase 2 trial exploring the effects of high‐dose (10,000 IU/day) vitamin D3 in breast cancer patients with bone metastases
https://onlinelibrary.wiley.com/doi/full/10.1002/cncr.24749

more for Vit D3
https://www.nature.com/articles/s41598-018-27297-1

https://www.nature.com/articles/s12276-018-0038-9



2 x Delta-Fraction Tocotrienals 125mg each (both with breakfast)

Brand: Life Extension available online at  i-herb.com.
Tocotrienols and Cancer: From the State of the Art to Promising Novel Patents.

https://europepmc.org/abstract/med/30652648

More about why I take the  delta fraction tocotrienals with the Garcinia

https://www.cancertreatmentsresearch.com/another-weak-spot-of-many-cancer-cells-atp-citrate-lyase-inhibition/?fbclid=IwAR2K0dqZrDVhLibkNHndgYmgwYo0B5e7uJWx0sc8kLTGVEWt4qeFMM0GLik



1 x Loratadine (mid morning)

being 1 tiny 10mg tablet about 2 hrs after lunch
metabolic pathway:  Glutamine/Macropinocytosis
Available over the counter at my local pharmacy

Effects of antihistamine use on survival in breast cancer.

http://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.e12527



4-5 drops of zinc chelate  whenever I have my liposomal vitamin c



1 x Vitamin B Complete Sustained Release (1 tablet with breakfast)

B complex available online at  i-herb.com.
B1 100mg,B2 80mg, B2 100mg,
B5 120mg,B6 75mg,Folic Acid 400mcg, B12 100mcg, Choline bitartrate 50mg, Inositol 50mg, Biotin 50mcg, Ascorbic Acid 200mg


 Iodine 

being potassium iodine available online at  i-herb.com.



Ginger Powder min 5g doses (all day with everything).

being organic ginger powder from online herb spice supplier

and available online at  i-herb.com.

I mix at least this amount (usually more) into my breakfast bowls and all teas and make sure it sits beside me at all meals.

Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells

https://www.sciencedirect.com/science/article/pii/S0955286307001337

Gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641128/


A minimum of 6g of Ascorbic Acid from 35ml Liposomal Vitamin C (around 4pm and again after dinner or even more often during the day if there are sick people about..e.g like this time of year in Australia)

Australian made pure liposomal Vitamin C without alcohol or soy.  I not only take this but I have been making it to order for others living in Australia since 2017. www.highdosevitaminc.com.au

LipoNaturals make another very good Liposomal Vitain C that is free from nasties and it is available online at  i-herb.com.


1/2 teaspoon x Ashwagandha (Indian Ginseng) mixed in evening tulsi tea.

being Ashwagandha powder from online herb supplier austral herbs, mixed into my  herbal tea one time each day.  Ashwgandha is aloso available online at i-herb.com.


1 x Magnesium Chelate (after dinner)

available online at  i-herb.com


180mg of ( super high dose pure) Melatonin about an hour or so before bed.

I worked my way up to this high dose at 10mg at a time usng the now foods 10mg from iherb only after working my way up to 10mg with the smaller dose capsules.
My 60mg pure Melatonin capsules are bought online from perfect vitamin however I wish to start buying the powder form pure bulk and making my own capsules to save money.

Melatonin–estrogen interactions in breast cancer
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-079X.2004.00207.x

Anti-aromatase effect of resveratrol and melatonin on hormonal positive breast cancer cells co-cultured with breast adipose fibroblasts. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/24929094

Watch this great presentation by Dr. Frank Shallenberger, the president of the American Ozone Therapy Association. Learn how pure Melatonin is being used in high doses with stage 4 cancer patients alongside inulin potentiated chemo therpay and ozone therapy here.

https://youtu.be/Roh4lQXneQg


I have also happily taken
200mg of a day Mebendazole
4 days on / 3 days off, each week for 6 weeks in early 2019.
And more recently for a week 200mg daily while alos adding 200mg Hydroxychloroquine and everythign else on my list..just for a week.

Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/


Zolodex Implant 1 x monthly
I am also in a state of chemically induced menopause from a
GnRH Analogue called Goserlin

brand name:
Zolodex (3.6mg implant)

Prescribed by my oncologist and given to me by my GP’s nurse once a month. This drug inhibits my ovaries from creating hormones.


To save you time, I have placed many or all the items listed above that are available online at iherb.com in an iherb.com  shopping basket. You can change the currency from my currency to yours at the top of the iherb page and you delete what you already have at home from the basket. This is the link to the view of the shopping basket : iherb basket 


.

 


 

2019 – off to a flying start

Jan 2019
Celebrating: learning, co-operation, support & flow
My (Australian) GP approved my use of Dipyridamole yesterday. The chemist will be able to fulfill prescription next week. I will start with 100mg each day for a week and build up to 200mg each day of a slow release tablet.

I have been researching the power of Dipyridamole to inhibit the spread of cancer since I first learnt about it in Jane McLelland’s, How to Starve Cancer book.
Along with Glucosamine Sulphate, Mebendazole & Aspirin, this Dipyridamole will seal the deal when it comes to stopping the release of growth factors/enzymes (VEGF’s & MMP’s) that break down the extracellular matrix and could allow my cancer to spread and grow.

I will just need to keep an eye on my blood pressure levels and make sure it does not get too low. The out of pocket cost is very low, but I will report back when I pick up the script next week.

I can’t recommend Jane McLelland’s book highly enough. “How to starve cancer without starving yourself”. I’ve heard the paper version is out of stock currently but I highly recommend the Kindle version for easy note taking, high-lighting cross-referencing and further online researching. https://www.amazon.com.au/Starve-Cancer-without-starving-yourself-ebook/dp/B07B2XMLT9

 

I  recently started utilizing the information in the book titled

“How to Starve Cancer without Starving Yourself” by Jane McLelland

and the “McLelland Metro Map” which is explained within the book.


My hope is that this year’s blog entries
will provide information
to the people that are supporting me,
in understanding exactly what it is
I’m doing in an attempt to
heal myself.


I also hope
that the order and accessibility
of the information on this site supports
anyone walking alongside me
on their own healing journeys.

Nothing written here on this site should be perceived as medical advice.

Feb 2019: Navigating The Book

Feb 2019
Celebrating: learning, integration & vitality

I feel as if I’m now fully embarking on a new leg of my cancer healing journey. I am currently still diagnosed with ‘stable’ stage 4 breast cancer ( which spread to bones in 2017).

I believe that living with cancer stem cells in my bones, even in a state of stability or non-progression, is NOT the future that I want for myself, or anyone else. We can do better!

“The ultimate life hack” is the how one of my friends with breast cancer describes the book by Jane McLelland that explains how to target cancer stem cells with affordable re-purposed medications and herbs.

Book Title: How to Starve cancer without Starving Yourself by Jane McLelland

There is a mountain of valuable information in the book that I have had to extract and personalize in order to present it to the people who are supporting me, such as my doctors, my friends and my family. I also imagine that many other people who are currently taking this approach or about to take on this approach might be interested in reading these notes too.

If this is your journey as much as it is mine, I encourage you to follow this blog and keep up to date with my progress and any changes I make along the way…and buy the book.

Once you have the book please join my private Facebook “How to Starve Cancer Book Study Support Group” . The group will help you to join in conversations with others who are figuring all this out alongside me. You can invite your friends to the group too via the ‘invite’ window on the group’s page. Update Note: As of May 5th to join the book group, you now need to be a member of Jane Mclelland’s group first. Her group is called “Jane McLelland Off Label Drugs for Cancer” You can use the groups as a way of learning, connecting and sharing your own cancer healing journey with myself and others too.

p.s..This  approach is actually designed for everyone with cancer. We are all in this together…breast, lung, colon..you name it. There will be something helpful for everyone with cancer in Jane’s  book. Being diagnosed stage 4 myself, I didn’t get too hung up on my phenotype as it’s well known that cancer is a slippery little eel at this point in it’s life, and I don’t feel comfortable leaving any metabolic pathway open for it to use.

So this is What I’m Doing…in February 2019

Using the book.

Step 1) 

Buy the electronic version of the book. Read the book thoroughly.
Make, a strictly personal-use only, copy of the McLelland Metro Map.
I had the electronic version of the book open on my i-pad and took a screen-shot of the screen. This screen-shot gets automatically saved as an image in my ‘all photos’ photo album on my i-pad.


NOTE: The McLelland Metro Map is only available (for personal use) to people who purchase the book:

How to Starve-Cancer without Starving Yourself by Jane McLelland.
I encourage everyone reading this page to please purchase the book, if you have not done so already. Trust me, if you have cancer, you don’t want to try and simply copy what someone else has done, without reading the book for yourself.

Here’s the Amazon Australia link to the electronic version I purchased to read on my Kindle App that I have on my i-pad and desktop:
https://www.amazon.com.au/Starve-Cancer-without-starving-yourself-ebook/dp/B07B2XMLT9

Step 2)
I opened the i-pad’s photo application and found the photograph of the map where I had saved it in my private photo album and then used a pen tool in the photo ‘edit’ program to ‘edit’ the screen shot image I took of the map.

Editing it involved choosing a pen tool from the tool pallet and running a green colored line under the names of drugs/medications/herbs I was able to access. And yes, of course, I could have also made a copy of the map on to paper and underlined it in pen, but for personal reasons chose to do this step on my screen.

More on purchasing the book;
I highly recommend anyone interested in killing cancer stem cells buy the electronic version of the book, as it the ongoing researching, is ‘super’ easy compared to using a paperback copy.
e.g when reading an electronic version of the book you can right click on any word and choose to “Search Google” for more info, or right click and choose to “search book”…wow..You can then read everything Jane wrote on that drug or topic. It saves a lot of time when you are piecing together the puzzle. You can also quickly highlight large areas and they are automatically saved to your Kindle or e-reader notes.

So this simple 2 step process above is where I started engaging with the metabolic pathways and what I could do to block them.

1) read book, copy map (for personal use only)
2) underline medications accessible to me in green.

e.g 

The medications accessible to me in Australia without prescription were the first to be underlined.

These were.
BERB being Berberine
LowGI
being the diet I was/am already on
EGCG 
being Green Tea
URS
being Tulsi tea
CURC
being Curcumin
HYDROXY
being Garcinia
RES being Resveratrol

Many people who I have engaged with, in the “How to Starve Cancer…” Facebook groups are taking this same, new and advanced metabolic approach to starving and killing caner stem cells, but with the help of an international oncology clinic.

Many of my fellow Facebook “How to Starve Cancer…” private group members from all over the world, are on, and/or at least considering ‘going to go on’ the Care Oncology Clinic (COC) complimentary off-label medicine protocol. The COC  is based in the U.K and U.S.A and consult with patients and thier GP’s from all over the world via Skype.

As I understand it, the COC doctors will communicate with their patient’s local GP (or at least a GP in the patient’s country, about getting on board and supporting the patient with a simple yet powerful complimentary approach to their current treatment.

The COC doctors provide the patient’s GP or oncologist with the understanding and confidence required to prescribe the complimentary off-label, FDA approved medications shown below.

(MET) Metformin
(STAT) Atorvastatin
(DOXY) Doxycycline
(MBZ)
Mebendazole

I believe that Care Oncology Clinic (COC) are currently (as of Jan, 2019) conducting self-funded research into this 4 drug metabolic approach to killing cancer stem cells ( all types of cancer) and are only prescribing these 4 complimentary medications (listed above) to each and every patient. I’m not doing this protocol. I may in the future.


Out of interest, I created a second personal copy of the McLelland Metro Map onto which I underlined in green just the COC prescribed medications. I compared the two maps.

I noticed right away that COC prescribed Mebendazole (MBZ) and it is not on the McLelland Metro map and so I did some more research. I discovered that it would be useful to anyone with any type of cancer, and that I could but it from the local chemist. I added it to my shopping list right away. ( I took fro 6 weeks and then stopped taking it, not because of any side effects, but thought I’d keep things simple and this one up my sleeve in case of progression)

When comparing the two maps, I did observe that the COC protocol was blocking many metro Map pathways with just a few medications. My first map showing the non-COC approach meant buying a larger quantity of meds/herbs and still there were gaps.

My personal leaning was towards the more natural herbal supps map I made first. I decided I would try to fill the map with the most natural over the counter medicines first and attempt to incorporate the COC drugs selectively if I ever needed to. That’s just who I am.

I connected with some of the people who were signed up to the COC protocol via my participation in the “How to Starve Cancer…” Facebook groups and soon discovered that many of them were taking a cocktail of cancer stem cell (CSC) metabolic pathway blockers including herbs and supplements ‘on top of’ the four main COC medications.

This led me to begin asking myself;
  “How many Metro Map  pathways do I need to block?” 

After giving this question some consideration I came to the conclusion that I would attempt to block them all and see how this felt.

This decision to BLOCK THEM ALL was based on the following:

My stage 2 diagnosis was made 5 years ago and after a mastectomy, and spell of ignorance my stage 4 diagnosis was made mid 2017 (almost 2 years ago). At this point in time I have no knowledge as to which metabolic pathways, if any, are currently up-regulated and/or which are likely to be up-regulated next. My breast cancer was last reported (Dec , 2018) to be stable, in my bones, (nowhere else) and I’m not willing to, or perhaps even able to, biopsy these bone lesions to obtain further information regarding their preferred energy sources etc..

I am sure I will in time, but for now I have no idea exactly what metabolic pathways my cancer stem cells prefer right now. So after reading the book I learnt that stage 4’s are really better off to be covering all of the pathways at once to reduce the risk of pushing the cancer to a more aggressive state. I will do that; Block them all ( or as many as I can)

The ER+ & PR+ ER- hormone receptor status of my breast cancer was reported via breast tissue biopsy when I was first diagnosed stage 2 in 2014.  I had a really crap alternative GP back in 2014. It’s almost impossible to believe now, but this really crap local GP advised me, , (me being someone who got a 95% ER+ via biopsy) against taking any hormone therapy. In fact she advised me against seeing an oncologist full stop. OMG, it’s frightening to think she’s still in practice. Anyway, I am very grateful now that I have both a great integrative GP and a great oncologist.


As far as my own personal hormone situation goes, I was still pre-menopausal, at the time of my secondary diagnosis (2017) and immediately awoke from my spell of ignorance placed on me by the 1st GP and went to and oncologist that started me on a monthly Goserlin (Zoladex) implant which stops my ovaries producing hormones, ( Plus I dove straight in with consistent use of high dose Vitamin C, the ketogenic diet for cancer -for at least 6 months, plus loads of ginger powder & curcumin with each meal. Please read www.healingbreastcancer.info for that leg of my journey. I didn’t know it at the time but the curcumin and high doses of vitamin C and the Zolodex were already blocking some of my cancer’s metabolic pathways.

O.K, so where am I …as of February 2019?

So I’m not blocking  them ‘all’ right now.