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What I am taking and why.

A whole day’s meds and supps: Current as of June 23rd  2019

1 x capsule Milk Thistle
available online at  i-herb.com

Each capsule contains mainly Milk Thistle and a little Globe Artichoke leaf.

There appears to be many studies on Pubmed suggesting that silymarin from Milk Thistle may exert a strong anticarcinogenic effect against many types of cancer, including breast cancer. It also and anti-oxidant and protects the liver and kidneys.
Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cycli… | Clinical Cancer Research

http://clincancerres.aacrjournals.org/content/4/4/1055.short

Silibinin Suppresses EGFR Ligand-induced CD44 Expression through Inhibition of EGFR Activity in Breast Cancer Cells
http://ar.iiarjournals.org/content/31/11/3767.shor


1 x big teaspoon organic Reishi mushroom powder (1 in afternoon tea )

I buy organic powder from my favorite Australian based online herb and spice supplier: https://www.australherbs.com.au/shop/item/reishi-mushroom-powder-organic
or from i-herb.com

Ganoderma lucidum extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267592/

Easy read on Reishi:
https://draxe.com/reishi-mushroom/


1 x Vitamin E (as d-alpha tocopherol) 400IU (1 with breakfast )

available online at  i-herb.com

I weigh 54kg so from what I can understand that means 1 a day is plenty to do the job. Someone heavier might take more each day.
Brand: A. C Grace Company ‘Unique E’ online from iherb.com

This page  summarises the findings on tocopherols being a potent aromatase inhibitor.
https://raypeatforum.com/community/threads/vitamin-e-tocopherol-is-a-potent-aromatase-inhibitor.

The mechanisms of anti-cancer activity of tocopherols 1) inhibition of ER (2) increasing peroxisome proliferator activated receptor γ (PPARγ) expression and activity, (3) induction of Nrf2, (4) antioxidative and anti-inflammatory activities, and (5) induction of apoptosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257724/

Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-γ
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753525/


1 x Quercetin 600mg (1/2 at lunch & at dinner )

available online at  i-herb.com
Metabolic Pathway inhibitor: Glucose/Glut 1 and Fatty Acid (FAS)

Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis

https://www.nature.com/articles/srep24049

Quercetin induces apoptosis in triple-negative breast cancer cells via inhibiting fatty acid synthase and β-catenin
http://www.ijcep.com/files/ijcep0036612.pdf


1 x Berberine 500mg (with breakfast & w lunch somedays dependnig on my menu)

available online at  i-herb.com

Multi Metabolic Pathway inhibitor:
SREBP-1 Acetate
SREBP-1
Insulin
OXPHOS
mTOR
Gln OXPHOS
and supresses hedgehog signalling

Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546096/

Berberine induces apoptosis in breast cancer cells through mitochondrial-dependent pathway
https://doi.org/10.1016/j.ejphar.2010.07.037

A growing body of reports supports the evidence that berberine has anticancer effects, being able to block the proliferation of and to kill cancer cells
https://www.sciencedirect.com/science/article/abs/pii/S000629521200500X

A neo-adjuvant endocrine trial showed a significant association between the increase of SREBP1 expression and lack of clinical response, providing further support for a role of SREBP1 in the acquisition of endocrine resistance in breast cancer.
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-018-1041-8

 

1 x Citrus Bergamot 500mg (1 whilst preparing dinner or lunch)

being Citrus Bergamia extract 500mg.  

Brand: Jarrow Formulas available online at  i-herb.com

Metabolic Pathway inhibitor: Fatty Acid/Mevolonate

Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism

https://www.sciencedirect.com/science/article/pii/S0005272818300616?via%3Di&fbclid=IwAR31J5Nb1c-FMAWiEF6xHNfDOvk-LoMW53B95BBnEqtMAwsZ7vNSgW2__GI

Molecular mechanisms of lipid- and glucose-lowering activities of bergamot flavonoids
https://www.sciencedirect.com/science/article/pii/S2213434415300220
 

1 & 1/2 x Garcinia 500mg (1/2 at beginning of each main meal)

being a cut- in-half tablet of Garcinia Cambogia extract 1000mg. So I’m getting  250mg Hydroxycitric Acid (HYDROXY) ad the rest is fruit of Garcinia Cambogia.

Brand: Jarrow Formulas available online at  i-herb.com

Metabolic Pathway inhibitor: Fatty Acid/ACLY
ACLY is a cross-link between glucose metabolism and fatty acid synthesis/mevalonate pathways controlled by SREBP-1. Potently inhibited by hydroxycitrate.
ATP Citrate Lyase Inhibitors as Novel Cancer Therapeutic Agents Recent Patents on Anti-Cancer Drug Discovery, 2012, 7, 154-167


6 x Curcumin 500mg
(2 at beginning of each main meal)

being Curcumin Phytosome with Meriva 500mg
I swallow with Tulsi tea for Ursolic Acid
Brand: Jarrow Formulas
available online at  i-herb.com
I swallow my curcumin capsules with Tulsi tea in which I’ve dissolved my Hu Zang for the ursolic acid / resv / curc combo effect.
Metabolic Pathway inhibitor: Glutamine/Glutaminolysis

A combination of ursolic acid and resveratrol or ursolic acid and curcumin prevents glutamine uptake by the cancer cell.

 

Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
https://www.nature.com/articles/s41698-017-0024-z

Unraveling the Anticancer Effect of Curcumin and Resveratrol
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133053/



Ursolic Acid (1- 2 cups  at beginning & end of each main meal)

being in Tulsi Tea (aka Holy Basil Tea) available online at  i-herb.com
I swallow my Curcumin capsules (see above) with 150ml of the strong Tulsi tea
Brand: I buy organic loose tea leaves in bulk online and drink with each meal. I will mix my other herbs and ginger in it too.

Metabolic Pathway inhibitor: Glutamine/Glutaminolysis 

see above study for Curcumin combo

Ursolic acid, a potential anticancer compound for breast cancer therapy. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/27469428

ECOTEAS Organic Tulsi | Tulsi Benefits
https://yerbamate.com/pages/tulsi-benefits



EGCG
Green Tea 150ml with breakfast and with morning tea

Brand: I buy organic green tea teabags online at  i-herb.com
Jane’s book says:
“EGCG  reduces angiogenesis and inhibitors of glutamate dehydrogenase (GHD), a precursor of glutamine (an amino acid), the other key nutrient cancer uses with glucose to fuel its growth. (
so…it’s in my map under Glutamine/Glutaminolysis)”
Mclelland, Jane. How to Starve Cancer …without starving yourself: The Discovery of a Metabolic Cocktail That Could Transform the Lives of Millions . Conscious Dreams Publishing. Kindle Edition.
More on this..
https://www.nature.com/articles/18793

And 10 health benefits of green tea supported by studies:
https://www.healthline.com/nutrition/top-10-evidence-based-health-benefits-of-green-tea#section10

1 x EGCG  capsule 98% Polyphenols (1 with dinner)

With dinner : De-caf Mega Green tea Extract 45% EGCG

Brand: Life Extension available online at  i-herb.com
Metabolic Pathway inhibitor: Glutamine/Glutaminolysis



2 x Nicotinamide / Vitamin B3 500mg
(1 with b’fast  1 x dinner)
being Nicotinamide 500mg (niacin flush-free)

 

available online at  i-herb.com

Metabolic Pathway inhibitor: Helps with all pathways in a complex manner

Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer
https://www.nature.com/articles/s41598-017-03322-7


Nicotinamide also protects the stomach mucus from damage caused by non-steroid anti-inflammatory drugs ( NSAIDs)

And more I’ve read on Nicotinamide / Vitamin B3

http://www.alternative-cancer-care.com/niacin-vitamin-b3-and-cancer.html?fbclid=IwAR31DQy6lWaIz3J4Or9r1Y_YIeP1mpf842KkStGTgJM-TBPXpLVN7i-8noQ



Valaciclovir 500mg x 1 with lunch

A herpes anti-viral drug prescribed by GP after I realized ( reading the book) that the cancer and virus could be closely linked.

Study shows specific type of herpes could cause breast cancer

https://www.healthimaging.com/topics/breast-imaging/study-shows-specific-type-herpes-could-cause-breast-cancer

 



1 x Dipyridamole 200mg  (1 at b’fast )
 

being 200mg (sustained release) 

Brand: Persantin available by prescription- and I was able to obtain due to it’s proven anti-viral action and my bloods showing herpes virus.
https://aac.asm.org/content/45/12/3657

Metabolic Pathway inhibitors: Glutamine/Nucleoside Salvage and the Fatty Acid/ SREBP-2

Dipyridamole is an old anti-platelet medication ( stops  blood cells sticking together and so stops them clustering and hiding cancer cells).

 

Dipyridamole starves cancer of the nucleotides and other proteins and enhances the effects of my anti-viral medication.

Selective potentiation of lometrexol growth inhibition by dipyridamole through cell-specific inhibition of hypoxanthine salvage
https://www.nature.com/articles/bjc1997552

Dipyridamole decreases platelet-derived growth factor levels in human serum.
https://www.ncbi.nlm.nih.gov/pubmed/3579723 


2 x Glucosamine Sulphate 750mg each (with lunch)
 
A matrix metallo-proteinase inhibitor available online at  i-herb.com.

Glucosamine sulfate suppresses the expression of matrix metalloproteinase-3 in osteosarcoma cells in vitro
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000453/


1g x Polygonum Cuspidatum Powder Extract  (1/3 g before each main meal)

being whole of Japanese Knotweed AKA Chinese herb Hu Zang powder 500mg dissolved in water and drunk. Metabolic Pathway inhibitors: Pentose Phosphate (P P Pathway) and likely more too. *Warning: not a safe supplement for “everyone” with breast cancer.. until you read this and your doctor agrees that it is not going to cause you harm in regards to estrogen do NOT take it:

Walking a Tightrope: A Perspective of Resveratrol Effects on Brea…: Ingenta Connect

https://www.ingentaconnect.com/content/ben/cpps/2018/00000019/00000003/art00008

A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo | Cell Death & Disease

https://www.nature.com/articles/s41419-018-0635-5?fbclid=IwAR1TwR87xCmFCTrp
JXVF_MLCI8WwJ3ldqOuX244XeZuHmpGORmLNm8Ea934

Polydatin, Natural Precursor of Resveratrol, Promotes Osteogenic Differentiation of Mesenchymal Stem Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036093/

 



1 x mini Aspirin 80mg  ( just before bed)

being one tablet in water.
Metabolic Pathway inhibitors: Fatty Acids/ FAS

“Aspirin and dipyridamole, both antiplatelet drugs, synergistically serve to break down the platelet clumps and expose the abnormal macrophages to the rest of the immune system”

“The ‘acetyl’ part of aspirin (acetyl salicylic acid) binds to the amino acid serine”

Mclelland, Jane. How to Starve Cancer …without starving yourself: The Discovery of a Metabolic Cocktail That Could Transform the Lives of Millions . Conscious Dreams Publishing. Kindle Edition.

Mechanism of the irreversible inhibition of human cyclooxygenase-1 by aspirin as predicted by QM/MM calculations.

https://www.ncbi.nlm.nih.gov/pubmed/23384979

Ray Peat, PhD on Aspirin – Functional Performance Systems (FPS)
https://www.functionalps.com/blog/2012/04/22/ray-peat-phd-on-aspirin/

https://cowseatgrass.org/2016/05/26/beware-when-rousing-the-bear-with-aspirin/?fbclid=IwAR103haIKFypLLQnzEgm0tjItVqWIOsiituVUNWOamiKG2x4G096v2mhD1U

I found this really interesting read in reference to reversing cancer with the help of high dose Aspirin.
http://www.fuckportioncontrol.com/blog/2016/12/21/cancer?rq=cancer&fbclid=IwAR17oqXoVReMDfy3gCzrazSQFjRiAGlxntSTh0TDO26jlRQaugDE66onqjM

Google: Nicotinamide (Vit  B3) protects the stomach mucus from damage caused by Aspirin


3 x Omega-7  450mg  (1 with each main meal)

being Sea Buckthorn Oil available online at  i-herb.com.
while I’m taking focusing on lowering cholesterol levels this is good oil.
https://www.sciencedirect.com/science/article/pii/S1756464611000028


Lots of Extra Virgin Olive Oil in breaky bowl & splashed on every meal

Modulation of inflammation and immunity by dietary conjugated linoleic acid



1 x Vitamin D3 5000iu with K2
(with b’fast)

being Colecalciferol and available online at  i-herb.com.

A phase 2 trial exploring the effects of high‐dose (10,000 IU/day) vitamin D3 in breast cancer patients with bone metastases
https://onlinelibrary.wiley.com/doi/full/10.1002/cncr.24749

more for Vit D3
https://www.nature.com/articles/s41598-018-27297-1

https://www.nature.com/articles/s12276-018-0038-9



2 x Delta-Fraction Tocotrienals 125mg (1 with b’fast, 1 w lunch)

 Only take when I’m not avoiding anti-oxidants that recycle glutithione.
as DeltaGOLDtm being 90% delta-trocotrienals and 10% gamma tocotrienals from Vitamin E.
Brand: Life Extension available online at  i-herb.com.
Tocotrienols and Cancer: From the State of the Art to Promising Novel Patents.

https://europepmc.org/abstract/med/30652648

More about why I take the  delta fraction tocotrienals with the Garcinia

https://www.cancertreatmentsresearch.com/another-weak-spot-of-many-cancer-cells-atp-citrate-lyase-inhibition/?fbclid=IwAR2K0dqZrDVhLibkNHndgYmgwYo0B5e7uJWx0sc8kLTGVEWt4qeFMM0GLik



1 x Loratadine (mid morning)

being 1 tiny 10mg tablet about 2 hrs after lunch
metabolic pathway:  Glutamine/Macropinocytosis
Available over the counter at my local pharmacy

Effects of antihistamine use on survival in breast cancer.

http://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.e12527

 



1 x Zinc tablet at night.

being Zinc amino acid chelate 100mg
Equiv elemental Zinc 20mg
Zinc sulfate monohydrate 68.7mg
Equiv elemental zinc 25mg
total elemental zinc 45mgB6 20mg
selenium 26 microgram
brand: Ethical Nutrients



1 x Vitamin B Complete Sustained Release (1 tablet with breakfast)

B complex available online at  i-herb.com.
B1 100mg,B2 80mg, B2 100mg,
B5 120mg,B6 75mg,Folic Acid 400mcg, B12 100mcg, Choline bitartrate 50mg, Inositol 50mg, Biotin 50mcg, Ascorbic Acid 200mg

 


 Iodine 

being potassium iodine available online at  i-herb.com.



Ginger Powder min 5g doses (all day with everything).

being organic ginger powder from online herb spice supplier

and available online at  i-herb.com.

I mix at least this amount (usually more) into my breakfast bowls and all teas and make sure it sits beside me at all meals.

Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells

https://www.sciencedirect.com/science/article/pii/S0955286307001337

Gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641128/


6g of Ascorbic Acid from 35ml Liposomal Vitamin C (around 4pm)

Australian made pure liposomal Vitamin C without alcohol or soy.  I not only take this but I have been making it to order for others living in Australia since 2017. www.highdosevitaminc.com.au

LipoNaturals make another very good Liposomal Vitain C that is free from nasties and it is available online at  i-herb.com.


1/2 teaspoon x Ashwagandha (Indian Ginseng) mixed in tea.

being Ashwagandha powder from online herb supplier austral herbs, mixed into my  herbal tea one time each day.  Ashwgandha is aloso available online at i-herb.com.


1 x Magnesium Chelate (after dinner)

available online at  i-herb.com


20mg of Melatonin about an hour or so before bed.

Melatonin–estrogen interactions in breast cancer
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-079X.2004.00207.x


I have also happily taken
200mg of a day Mebendazole
4 days on / 3 days off, each week for 6 weeks in early 2019.

Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/


Zolodex Implant 1 x monthly
I am also in a state of chemically induced menopause from a
GnRH Analogue called Goserlin

brand name:
Zolodex (3.6mg implant)

 

Prescribed by my oncologist and given to me by my GP’s nurse once a month. This drug inhibits my ovaries from creating hormones.


To save you time, I have placed all the items listed above that are available online at iherb.com in an iherb.com  shopping basket. You can change the currency from my currency to yours at the top of the iherb page and you delete what you already have at home from the basket. This is the link to the view of the shopping basket : iherb basket 



A list of Metabolic pathways I have inhibited :

My Glutamine Pathway Inhibitors
IGF-1
Goserlin (Zolodex) implant each month from oncologist

Gln OXPHOS
Berberine
(+ Niclosamide in draw in case of trouble)

mTOR:
Berberine

Macropinocytosis:
Loratadine
(+ Hydroxy Chloroquine in draw in case of trouble)

Nucleoside Salvage:
Dipyridamole

Glutaminolysis:
EGCG in Green Tea,
Curcumin phytosome with meriva.
washed down with Ursolic Acid in Tulsi Tea,
and a teaspoon of Japanese Knotweed aka Hu Zang root from which RESveratrol comes (see important warning below),

Walking a Tightrope: A Perspective of Resveratrol Effects on Brea…: Ingenta Connect

https://www.ingentaconnect.com/content/ben/cpps/2018/00000019/00000003/art00008

*Warning: not a safe supplement for everyone with breast cancer.. until you read this and your doctor agrees that it is not going to cause you harm in regards to estrogen do NOT take it.



Glucose Pathways Inhibited

Glut 1:
Quercetin,
Curcumin phytosome with meriva,
Liposomal vitC

Insulin:
Low GI Diet,
Walk after meal,
Berberine,

PP Pathway:
Keto-7 DHEA,
Japanese Knotweed aka Hu Zang root powder
again a warning goes with this supplement

Walking a Tightrope: A Perspective of Resveratrol Effects on Brea…: Ingenta Connect

https://www.ingentaconnect.com/content/ben/cpps/2018/00000019/00000003/art00008

*Warning: not a safe supplement for everyone with breast cancer.. until you read this and your doctor agrees that it is not going to cause you harm in regards to estrogen do NOT take it.

OxPhos:
Berberine

Aerobic Glycolosis
Liposomal Vitamin C


Fatty Acid Pathway Inhibitors
SREBP-1 Acetate:
Berberine

ACLY:
Garcinia Cambogia plus Alpha Lipoic Acid

F.A.S:
Mini Aspirin

F.A.O:

Nicotinamide ( flush free niacin) ,
Niacin
Avoiding rancid oils adding extra good olive oil, + omega 3, 6 and 7

SREBP-1:
Berberine

Mevolonate:
Citrus Bergamot

SREBP-2:
Dipyridamole

Abnormal Cell Signalling
Sonic Hedgehog

Abnormal in many cancers including breast cancer:

The role of the Hedgehog signaling pathway in cancer: A comprehensive review. – PubMed – NCBI

https://www.ncbi.nlm.nih.gov/pubmed/29274272

Inhibitors: Berberine, Metformin, Mebendazole

Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546096/

 

Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer. – PubMed – NCBI

https://www.ncbi.nlm.nih.gov/pubmed/25999130

 

Multi-targeted therapy of cancer by niclosamide: a new application for an old drug

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166407/

 

WNT signaling deregulation induces bone metastases in breast cancer:


WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth
https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr2317

 

WNT Regulators: Aspirin, Dipyridamole, Niclosamide, Vitamin D3, NSAIDs,

A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963808/

Notch
Notch signaling has a role in breast cancer:

The Notch Pathway in Breast Cancer Progression

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077551/

Notch Regulators: Luteolin, Sulforaphane, Quercetin, Niclosamide

Mechanism of metastasis suppression by luteolin in breast cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003288/

Notch Activation Is Dispensable for D, L-Sulforaphane-Mediated Inhibition of Human Prostate Cancer Cell Migration
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044957

Notch Inhibitors for Cancer Treatment

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732476/


Toll Like Receptors (TLR’s) and Breast cancer: TLR’s-3, 4 & 9
Studies Indicate:
Berberine, Low dose naltrexone (LDN), and Hydroxychloroquine 

Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis | BMC Cancer | Full Text
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-10-665

TLR4 Promotes Breast Cancer Metastasis via Akt/GSK3β/β-Catenin Pathway upon LPS Stimulation. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/28296189

Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/29365334

Low dose naltrexone (LDN) US20180207263A1 – Treatment of cancer with naltrexone – Google Patents
https://patents.google.com/patent/US20180207263A1/en

Hydroxychloroquine efficiently suppresses inflammatory responses of human class-switched memory B cells via Toll-like receptor 9 inhibition. – PubMed – NCBI https://www.ncbi.nlm.nih.gov/pubmed/29981383

Recent progress in the development of Toll-like receptor (TLR) antagonists: Expert Opinion on Therapeutic Patents: Vol 26, No 6
https://www.tandfonline.com/doi/abs/10.1080/13543776.2016.1185415


Integrins contribute to the development and progression of tumors in breast cancer
Studies indicate: Dipyridamole

Increased β1 Integrin Is Associated with Decreased Survival in Invasive Breast Cancer | Cancer Research
http://cancerres.aacrjournals.org/content/67/2/659.short

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies | JCB

http://jcb.rupress.org/content/137/1/231.abstract

Integrin activation controls metastasis in human breast cancer | PNAS
https://www.pnas.org/content/98/4/1853.short

Dipyridamole enhances an anti‐proliferative effect of interferon in various types of human tumor cells – Suzuki – 1992 – International Journal of Cancer – Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.2910510420

Inhibition of Metastases by Anticoagulants | JNCI: Journal of the National Cancer Institute | Oxford Academic

https://academic.oup.com/jnci/article/91/1/22/2549


Estrogen is strongly linked to many breast cancers.
Studies indicate: Hormone therapies incl. Goserlin (my monthly Zolodex implant from my oncologist), Melatonin and Tocopherols

Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms – Amin – 2019 – Journal of Cellular Biochemistry – Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28832

Frontiers | Co-administering Melatonin with an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-positive Breast Cancer | Oncology
https://www.frontiersin.org/articles/10.3389/fonc.2019.00525/abstract

Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-γ
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753525/



EGFR

Studies Indicate: Berberine, EGCG, Curcumin


Interleukins
are linked to progression in Breast Cancer
Studies Indicate: NSAID’s, Aspirin


PPAR In many cancers doesn’t contribute to start of Breast Cancer but does progress in later stages
Studies Indicate: Citrus Bergamot, Berberine , Fish oils (Omega-3), Vit -A and Vit-D and Sea Buckthorn Oil (Omega -7)

My “How to Starve Cancer… Study Support Group”
https://www.facebook.com/groups/starvecancer/ is a 2000+ member strong cancer study group (on Facebook). It is currently in secret mode so you will first need to find me on Facebook and make a friend request with an accompanying Facebook message that will let me know you want to join this study support group. A reply message will come directly from me. http://www.facebook.com/abbey.mitchell.71

Free 60 min Support Calls

Feeling overloaded and want book a support call with me?

I offer 60 minute Facetime support calls. Use the contact page to let me know your time zone and best days and times and the area in which you would love to receive some of my support. My own time zone is SYD, Australia AEST and I’m available between 8am – 8pm most days. I do not charge for my suport calls, and I am equally open to receiving a gift from you in return for my time. Any such gift can be made at your own discretion and in your own time; based entirely on whatever feels most comfortable and good for you to give, if it does after the call.
Abbey

.

 


 

2019 – off to a flying start

Jan 2019
Celebrating: learning, co-operation, support & flow
My (Australian) GP approved my use of Dipyridamole yesterday. The chemist will be able to fulfill prescription next week. I will start with 100mg each day for a week and build up to 200mg each day of a slow release tablet.

I have been researching the power of Dipyridamole to inhibit the spread of cancer since I first learnt about it in Jane McLelland’s, How to Starve Cancer book.
Along with Glucosamine Sulphate, Mebendazole & Aspirin, this Dipyridamole will seal the deal when it comes to stopping the release of growth factors/enzymes (VEGF’s & MMP’s) that break down the extracellular matrix and could allow my cancer to spread and grow.

I will just need to keep an eye on my blood pressure levels and make sure it does not get too low. The out of pocket cost is very low, but I will report back when I pick up the script next week.

I can’t recommend Jane McLelland’s book highly enough. “How to starve cancer without starving yourself”. I’ve heard the paper version is out of stock currently but I highly recommend the Kindle version for easy note taking, high-lighting cross-referencing and further online researching. https://www.amazon.com.au/Starve-Cancer-without-starving-yourself-ebook/dp/B07B2XMLT9

 

I  recently started utilizing the information in the book titled

“How to Starve Cancer without Starving Yourself” by Jane McLelland

and the “McLelland Metro Map” which is explained within the book.


My hope is that this year’s blog entries
will provide information
to the people that are supporting me,
in understanding exactly what it is
I’m doing in an attempt to
heal myself.


I also hope
that the order and accessibility
of the information on this site supports
anyone walking alongside me
on their own healing journeys.

Nothing written here on this site should be perceived as medical advice.

Protection against regular cancer screening procedures.

Here’s a link to a great interview for anyone with cancer to hear. It was most valuable for me to listen to, as I am booked in for both an MRI (with ‘no’ contrast fluids) of my spine and a full body bone scan on the same day to monitor my situation.
The role of high dose vitamin C to support us in protecting our healthy cells while living with cancer scanning appointments and conventional treatment choices is discussed.

16 Months after secondary breast cancer diagnosis

It’s now Nov 1st 2018 and my oncologist told me last week that my breast cancer tumor markers have dropped even further. They are now 16. I’m feeling magnificent and I will be getting an MRI of my spine next month to see how my Lumbar region is looking.
I’m currently not taking as many supplements as I was previously. This is what I’m taking currently:

I’m adding plenty of organic turmeric & ginger powder to breakfast, all cups of tea &  to my dinner. I drink organic Chrysanthemum tea with Marshmallow root with some organic ginger and turmeric powder in that too.

I am still loving my breakfast bowl of soaked chia, with 1 tspn chlorella powder, whole lemon juice to taste, soaked organic goji berries, 1 tspn organic ginger powder  & 1 tspn organic rose-hip powder. Lunches are organic vegetable salads with sauerkraut, sometimes mackerel or chicken & avocado with lightly toasted pumpkin seeds and sunflower seeds.

Over the past couple of months I have enjoyed reading the book Radical Remission and the book, Molecules of Emotion. Both have provided me with the opportunity to reflect more deeply on how my emotional state and my sub-conscious state (the body’s intelligence systems of information and energy we call the mind) influence my healing of secondary breast cancer and my ability to maintain my good health going forward.

I now know how to muscle test (communicate with my sub-conscious mind about my body’s needs), and for the past 6 weeks I have used  The Emotion Code to release trapped emotions from my body. I’ve found the releasing of trapped emotional baggage to be incredibly powerful. Physical conditions which I thought were never going to go away just left – And emotions which I thought were outside of my direct influence, left like a switch was flicked – gone!. I am so impressed with the power of this work that I am now completing The Emotion Code practitioner training so I can support others to release their emotional baggage that is causing stress in their bodies, their life  and in their relationships with others. We all deserve to feel this good!

I’m aiming to have completed my training by the end of 2018. As a part of my training requirements, I’m looking for volunteers for free sessions with me (November/ December 2018). So, if you are in pain or have a nagging physical condition that you just can’t seem to get over, or blocks to the kind of relationships or life you desire, please get in touch. It is very likely that trapped emotions are getting in the way of your full recovery, your total well-being & your alignment with your highest good.  Please contact me if you are interested in booking a free 45min Release Session with me in 2018. These can be done both via video call and in person.

I’ll check back in, in late December to share my  MRI results with you.
x Abbey

High Dose Vitamin C and Cancer: Video

This Chris Wark video interview (see below) is with Ron Hunninghake, MD, the world-renowned expert on the use of vitamin C for cancer and other ailments. Dr. Hunninghake has overseen more than 75,000 administrations of IV vitamin C while serving as Medical Director at the Riordan Clinic, since 1989.

“I have personally experienced many wonderful benefits of supplementing with high dose vitamin C in the form of liposomal vitamin C and believe this video is a must watch, for anyone dealing with any stage of cancer or prevention of cancer”.

The video (below) has been created and offered to us free of charge, by Chris Wark of the ‘Chris Beat Cancer’, healing resource website. Like much of what Chris Wark brings forth into the world, it contains highly valuable information we can all easily utilise in our quest to enhance the quality of our health, the levels of our energy and perhaps even the length of our (one very precious) life.

Be sure to take some notes and listen out for…
-The dosing variances of vitamin C [12:14]
-The perfect adjunctive therapy [19:00]
-How vitamin C kills cancer cells [22:00]
-The Trojan Horse cancer theory [26:33]
-The medicine of the future [31:05]
-Comparing types of vitamin C: liposomal/crystals/buffered [36:30]
-Targeting nutrient deficiencies in cancer patients [43:45]
-The importance of having a reason to live [51:35]
-The alienation accompanying a cancer diagnosis [56:12]
-Other recommended IV therapies [59:04]
-The rise of IV vitamin C in conventional medicine [1:02:40]
-How certain deficiencies might lead to mental illness [1:06:38]

As someone diagnosed in 2017 with secondary breast cancer, who is now thriving thanks to high dose vitamin C, I  feel very strongly about spreading the word about high dose vitamin C. I even created a website dedicated to all things high dose vitamin c.

I hope you head over to my high dose vitamin c site and decide to learn more, especially about liposomal vitamin C. the latest form of high dose vitamin C way more accessible and affordable than intravenous vitamin C.

One Year from Secondary Breast Cancer Diagnosis

I haven’t stopped to write anything here since my last visit to the oncologist ‘because life has just been so go-go-go!’ My little Liposomal Vitamin C making service has found its feet and is adding to the busy-ness…ahhh that’s what it’s called a business! It keeps you so busy.

There was unexpected good news from the oncologist. I hadn’t stopped to imagine that my breast cancer tumour markers would continue to drop as they were already down to 25 at last count. The normal range is 0>30, and they where once at 51; that was a year ago when my scans showed breast cancer metastasis in seven places throughout my skeletal system. Now they are 19!

The latest CT scan showed ‘nothing’ apart from already seen and stabilised activity within the bones. The bone scan report showed no progression. My breast cancer tumor markers dropped even further. I was already back in the ‘normal’ range, now I must be in the super healthy person range for sure because I’m feeling amazing!
After the above mentioned results came in, I went for an ultrasound to examine areas on my chest wall, armpits and right breast where active breast cancer tumors were confirmed via biopsy last June. There was nothing there. Yes, all three confirmed tumors that originally led me to CT, PET and bone scans and the diagnosis of secondary cancer throughout my skeletal system, have now completely vanished. How exciting! Could the same be happening throughout my body. I am choosing to  believe it is.

Everyday I’m exercising vigorously to oxygenate my whole body for thirty minutes, followed by a 30 minute sauna and Qi Gong.  I’m taking many supplements to support the healing process

At least 10g of vitamin C in the form of Liposomal Vitamin C,

10g of Modified Citrus Pectin

2-3G of Curcumin Phytosome with Meriva,

3 tspns of Biohawk Relief Ginger Enzymes,

4 x Algae Cal Calcium plus D3 & K2 capsules,

1 x capsule 300mg Ubiquinol bioactive CoQ10,

1500 mg of flush free niacin and

1-2 teaspoon of super green powder

Eagle Brand Magnesium and Zince and B’s

plus variety of fresh probiotics.

I’m feeling full of energy all day and sleeping well.

Abbey

Diagnosis Shock and Stressfr

When I first got the news from my breast surgeon, in June 2017, that the breast cancer was back and  had found its way into about 7 places in my bones I was deeply shocked. The first month or two after diagnosis of stage 4 cancer was overwhelming. I got a horrible response and no support from my original GP, and then a couple of weeks later went on Zolodex hormone blockers as prescribed by my oncologist. My adrenal system was well into over-drive. I speak to other people each week who are in similar ‘totally shocked, exhausted and or highly stressed’ early stages of healing,  and my hope is that my story below will be helpful to one of these dear souls

When I got my secondary breast cancer diagnosis I went to see my then GP, who at the time was is well known in the area to offer alternative medicines and referrals to her patients. The earliest possible appointment for me to see her was two weeks after I found out the news of metastasis. During the two week period I waited to see her, I was online researching hormone receptor positive breast cancer treatments and talking to my very supportive breast surgeon in Brisbane, Dr. Christopher Pyke.  I had regular contact with Dr. Pyke, after my stage 2 mastectomy in 2014. He saw me each year and ordered my MRI scans and had also ordered my PET & CT scans after the MRI in May 2017 found three spots which led to three biopsies, all of which returned the news that the breast cancer was in my lymph nodes and remaining breast tissue.

So, in the first two weeks after the CT and PET confirming secondary breast cancer to the bones, I was spending  a lot of time online researching the new ketogenic diet I was on, and learning about the conventional hormone therapies that Dr. Pyke had told me about. Before I got in to see my then GP, I had already come to the conclusion that I would ask her for a referral for the Cancer Institute in Coffs Harbour where I could speak to the oncologist hear what she had to say about the various hormone treatments available.

When I went in to see her, I let her know I was there to obtain a referral to the oncologist; she sat and nodded. I then asked her if she could refer me to a good dietician as I was seeking support and some assurance in regards to  the ketogenic diet. Her response was. ‘the cancer institute has a dietician, speak to them’. Then my next question to her was regarding a referral to a good exercise physiologist so I could  learn how to best support the specific muscles near the tumour on my L3. Her response to this was exactly the same as the first response; ‘the cancer institute has a physiotherapist you can speak to’.

So now, I’m sitting there barely five minutes into our appointment time, wondering what else I had on my list. My partner Neil looks up from his empty note pad ( his job is to write down what the doctors say) and he asks her “So what can you do for Abbey?” Her response to this question was shocking and what I believe sent me from manageable stress, into adrenal over-drive. Her words, no joke, were these;
“Come back to me when you need me to write you a referral to palliative care.”
Hearing these words I stood up to leave her office as I knew then that she was not interested in practicing integrative health, only alternative.

Note to all the newly diagnosed: Be aware of the difference between alternative and integrative when seeking a good GP.

I had seen this same alternative GP back in 2014 when I had 3 lobular carcinoma lumps detected in my left breast. Back then, she talked about the oncologist and the hormone treatment in a way, that easily persuaded me not to go that path. She did not encourage me to be brave and learn all I could; instead she spoke to me about estrogen-less sagging breasts and dry vaginas. She advised me to increase the time I spent on my meditation and Qi Gong practices and make monthly appointments with her colleague, a very alternative energy healer. She made no suggestion that I return see her for blood tests regularly or anything else, after my post mastectomy check up in April 2014.

So here I was 3 years later, in June 2017 walking out of her office (for the last time) with a referral to the oncologist but no other professional support in place. It was only after a month or so, of not knowing who to turn to, that a series of almost magical events led me to a really wonderful local integrative GP, Dr. Adrian Hekel.

When Dr. Hekel asked me why I was there, I told him about my need to have an integrative doctor, someone outside the cancer institute to walk beside me and support me in doing the very best I could to get through this. I asked if he could find me the diet and physio support, and he did. I also told him about the mental, emotional and physical side effects of the chemical menopause. I had just begun a monthly Zolodex implant and was an emotional  mess.

After my second appointment at Northside Health, and a thorough biopsychosocial evaluation, Dr. Hekel suggested I try  a supplement, the Metagenics brand of AdrenoTone tablets. The idea was that they would support my adrenals replenish after the shocking diagnosis and the effects of  drastic hormonal manipulation. The herbs in the AdrenoTone product quickly agreed with me, and my ability to cope with situation on all levels improved rapidly.

I am so grateful that I was supported at this level, when I was. This integrative support enabled me to regain and focus my energy and emotions, and direct them toward my healing goals.

One of the herbs in the AdrenoTone was Siberian Ginseng , and I’m sure my oncologist would not have been happy with me using it. Siberian ginseng ‘might’ act like estrogen, Estrogen being the hormone the oncology injection was blocking. The official word of caution is “If you have any condition that might be made worse by exposure to estrogen, don’t use Siberian ginseng.” I decided for myself within days that if taking it was improving my quality of life this dramatically that I would continue to take it ‘short term and not long term’. Just long enought to get me through the overwhelm, shock and stress period.

Ashwagandha was another herb in the AdrenoTone tablets, however it that was not going to be an estrogen issue. I did go out and buy a large bag of Aswagandha from Noodles Emporium on Ebay. Ashwagandha really helped me in smoothing out the early days of overnight menopause madness. I still have some in my kit, which I take from time to time.

I wrote this because I care about so many of the people I speak to each week who are reeling in shock and confusion like I once was; unable to think straight or keep it together emotionally. I firmly believe that replenishing our adrenals during times of  deep shock and great stress is the best place to start the healing process. Being in that sustained state of fright, flight or freeze post diagnosis does not help the body heal one bit. I believe that the stress occurring around the time of diagnosis can be outright highly dangerous in itself without the right integrative care and adrenal support.

Thank-you Dr. Hekel for offering me this support at the start of my own healing journey.